Dynamic relocalization of replication origins by Fkh1 requires execution of DDK function and Cdc45 loading at origins

Dynamic relocalization of replication origins by Fkh1 requires execution of DDK function and Cdc45 loading at origins

Chromosomal DNA elements are organized into spatial domains within the eukaryotic nucleus. Sites undergoing DNA replication, high-level transcription, and repair of double-strand breaks coalesce into foci, although the significance and mechanisms giving rise to these dynamic structures are poorly un...

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Bibliographic Details
Main Authors: Haiyang Zhang, Meghan V Petrie, Yiwei He, Jared M Peace, Irene E Chiolo, Oscar M Aparicio
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-05-01
Series:eLife
Subjects:
replication origin
nucleus
forkhead
chromosome
replication timing
nuclear mobility
Online Access:https://elifesciences.org/articles/45512

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