Association analysis and functional follow-up identified common variants of JAG1 accounting for risk to biliary atresia

Association analysis and functional follow-up identified common variants of JAG1 accounting for risk to biliary atresia

Background: Biliary atresia (BA) is a destructive, obliterative cholangiopathy characterized by progressive fibro-inflammatory disorder and obliteration of intra- and extrahepatic bile ducts. The Jagged1 (JAG1) gene mutations have been found in some isolated BA cases. We aim to explore the associati...

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Bibliographic Details
Main Authors: Mei-Rong Bai, Hao-Yue Pei, Ying Zhou, Huan-Lei Song, Wei-Hua Pan, Yi-Ming Gong, Wen-Jie Wu, Wen-Wen Yu, Meng-Meng Cui, Bei-Lin Gu, Xun Chu, Wei Cai
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Genetics
Subjects:
biliary atresia
JAG1
single nucleotide polymorphisms
zebrafish
bile ducts
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1186882/full

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https://www.frontiersin.org/articles/10.3389/fgene.2023.1186882/full

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