Human umbilical cord blood-derived MSCs trans-differentiate into endometrial cells and regulate Th17/Treg balance through NF-κB signaling in rabbit intrauterine adhesions endometrium

Human umbilical cord blood-derived MSCs trans-differentiate into endometrial cells and regulate Th17/Treg balance through NF-κB signaling in rabbit intrauterine adhesions endometrium

Abstract Purpose The fundamental cause of intrauterine adhesions (IUAs) is the destruction and reduction in stem cells in endometrial basal layer, resulting in endometrial reconstruction very difficult. The purpose of this study was to investigate the effects and underlying mechanism of human umbili...

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Bibliographic Details
Main Authors: Qing Hua, Yong Zhang, Hongjuan Li, Haoran Li, Ranran Jin, Li Li, Yuancui Xiang, Meng Tian, Jingjing Wang, Lei Sun, Yali Wang
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Stem Cell Research & Therapy
Subjects:
Intrauterine adhesion (IUA)
Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs)
scRNA-seq
Trans-differentiation
NF-κB signaling
Online Access:https://doi.org/10.1186/s13287-022-02990-1

Internet

https://doi.org/10.1186/s13287-022-02990-1

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