G protein coupled receptor 41 regulates fibroblast activation in pulmonary fibrosis via Gαi/o and downstream Smad2/3 and ERK1/2 phosphorylation

G protein coupled receptor 41 regulates fibroblast activation in pulmonary fibrosis via Gαi/o and downstream Smad2/3 and ERK1/2 phosphorylation

Pulmonary fibrosis is a progressive and fatal fibrotic lung disease with mysterious pathogenesis and limited effective therapies. G protein-coupled receptors (GPRs) participate in a variety of physiologic functions, and several GPRs have critical fibrosis-promoting or -inhibiting roles in pulmonary...

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Bibliographic Details
Main Authors: Zhengnan Ren, Xiaohua Pan, Jiahong Li, Xiaoliang Dong, Xing Tu, Li-Long Pan, Jia Sun
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Pharmacological Research
Subjects:
Pulmonary fibrosis
G protein coupled receptor 41
Extracellular matrix
Fibroblasts
Gαi/o
Online Access:http://www.sciencedirect.com/science/article/pii/S104366182300110X

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http://www.sciencedirect.com/science/article/pii/S104366182300110X

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