Identification of Pinosylvin in <i>Pinus nigra</i> subsp. <i>laricio</i>: A Naturally Occurring Stilbenoid Suppressing LPS-Induced Expression of Pro-Inflammatory Cytokines and Mediators and Inhibiting the JAK/STAT Signaling Pathway

Identification of Pinosylvin in <i>Pinus nigra</i> subsp. <i>laricio</i>: A Naturally Occurring Stilbenoid Suppressing LPS-Induced Expression of Pro-Inflammatory Cytokines and Mediators and Inhibiting the JAK/STAT Signaling Pathway

Stilbenoids, a group of phytoalexin polyphenols produced by plants as a defence mechanism in response to stress conditions, are known for their anti-inflammatory potential. Pinosylvin, a naturally occurring molecule traditionally found in pinus trees, was here identified in <i>Pinus nigra</...

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Bibliographic Details
Main Authors: Maria Rosaria Perri, Michele Pellegrino, Mariangela Marrelli, Stefano Aquaro, Fabiola Cavaliere, Fedora Grande, Maria Antonietta Occhiuzzi, Carmine Lupia, Claudia-Crina Toma, Filomena Conforti, Giancarlo Statti
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Pharmaceuticals
Subjects:
HPLC
IL-6
inflammation
molecular docking
<i>Pinus</i> extract
RAW 264.7
Online Access:https://www.mdpi.com/1424-8247/16/5/718

Internet

https://www.mdpi.com/1424-8247/16/5/718

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