Lathosterol Oxidase (Sterol C-5 Desaturase) Deletion Confers Resistance to Amphotericin B and Sensitivity to Acidic Stress in <named-content content-type="genus-species">Leishmania major</named-content>

Lathosterol Oxidase (Sterol C-5 Desaturase) Deletion Confers Resistance to Amphotericin B and Sensitivity to Acidic Stress in <named-content content-type="genus-species">Leishmania major</named-content>

ABSTRACT Lathosterol oxidase (LSO) catalyzes the formation of the C-5–C-6 double bond in the synthesis of various types of sterols in mammals, fungi, plants, and protozoa. In Leishmania parasites, mutations in LSO or other sterol biosynthetic genes are associated with amphotericin B resistance. To i...

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Bibliographic Details
Main Authors: Yu Ning, Cheryl Frankfater, Fong-Fu Hsu, Rodrigo P. Soares, Camila A. Cardoso, Paula M. Nogueira, Noelia Marina Lander, Roberto Docampo, Kai Zhang
Format: Article
Language:English
Published: American Society for Microbiology 2020-08-01
Series:mSphere
Subjects:
Leishmania
amphotericin
drug resistance mechanisms
lipid synthesis
sterols
stress response
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00380-20

Internet

https://journals.asm.org/doi/10.1128/mSphere.00380-20

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