Enhancement of the neutralization ability resulting from a single amino acid change in the light chain of a chimeric antibody against SARS-CoV-2
Objective·To screen the human-mouse chimeric antibodies that neutralize the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and analyse the key amino acid site changes in their light chain.Methods·Antibody heavy chain gene-humanized mice were immunized with the spike protein of SARS-Co...
| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | zho |
| Publicado em: |
Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science)
2023-06-01
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| Colecção: | Shanghai Jiaotong Daxue xuebao. Yixue ban |
| Assuntos: | |
| Acesso em linha: | https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-6-718.shtml |