Gut–microbiota–microglia–brain interactions in Alzheimer’s disease: knowledge-based, multi-dimensional characterization

Gut–microbiota–microglia–brain interactions in Alzheimer’s disease: knowledge-based, multi-dimensional characterization

Abstract Background Interactions between the gut microbiota, microglia, and aging may modulate Alzheimer’s disease (AD) pathogenesis but the precise nature of such interactions is not known. Methods We developed an integrated multi-dimensional, knowledge-driven, systems approach to identify interact...

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Bibliographic Details
Main Authors: QuanQiu Wang, Pamela B. Davis, Xin Qi, Shu G. Chen, Mark E. Gurney, George Perry, P. Murali Doraiswamy, Rong Xu
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Alzheimer’s Research & Therapy
Subjects:
Gut microbiota
Neurodegeneration
Microglia
Microbial metabolites
Systems biology
Networks
Online Access:https://doi.org/10.1186/s13195-021-00917-1

Internet

https://doi.org/10.1186/s13195-021-00917-1

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