Axon terminal hypertrophy of striatal projection neurons with levodopa-induced dyskinesia priming

Axon terminal hypertrophy of striatal projection neurons with levodopa-induced dyskinesia priming

BackgroundA rat model of levodopa-induced dyskinesia (LID) showed enlarged axon terminals of striatal direct pathway neurons in the internal segment of the globus pallidus (GPi) with excessive gamma-aminobutyric acid (GABA) storage in them. Massive GABA release to GPi upon levodopa administration de...

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Bibliographic Details
Main Authors: Takashi Nakamura, Haruo Nishijima, Fumiaki Mori, Iku Kinoshita, Tomoya Kon, Chieko Suzuki, Koichi Wakabayashi, Masahiko Tomiyama
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Neuroscience
Subjects:
GABA
abnormal involuntary movement
synaptic plasticity
priming
levodopa-treated rats
synaptic vesicles
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1169336/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2023.1169336/full

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