(−)-Gossypol Inhibits Growth and Promotes Apoptosis of Human Head and Neck Squamous Cell Carcinoma In Vivo

(−)-Gossypol Inhibits Growth and Promotes Apoptosis of Human Head and Neck Squamous Cell Carcinoma In Vivo

Resistance to chemotherapy is a common problem encountered in the treatment of head and neck squamous cell carcinoma (HNSCC). Chemoresistant HNSCC tumors frequently overexpress antiapoptotic proteins, such as BCI-xL. (−)-Gossypol, the negative enantiomer of a cottonseed polyphenol, binds to BCI-xL a...

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Bibliographic Details
Main Authors: Keith G. Wolter, Steven J. Wang, Bradley S. Henson, Shaomeng Wang, Kent A. Griffith, Bhavna Kumar, Jianyong Chen, Thomas E. Carey, Carol R. Bradford, Nisha J. D'Silva
Format: Article
Language:English
Published: Elsevier 2006-03-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Chemoresistance
(−)-gossypol
head and neck cancer
oral cancer
Bcl-xL
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558606800448

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http://www.sciencedirect.com/science/article/pii/S1476558606800448

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