The effect of the tumour necrosis factor-alpha-inhibitor etanercept on microglial activation patients with mild cognitive impairment—a PET study

Aim: Microglial activation is increasingly recognised as a factor in the progression of Alzheimer’s disease (AD) and may be modified by systemic inflammatory signals including serum tumour necrosis factor (TNF)-α. The aim was to investigate whether blockade of peripheral TNF-α with peripheral inhibi...

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Bibliographic Details
Main Authors: Alexander Gerhard, Richard Sharples, Tsepo Goerttler, Kathryn McDonald, Eszter Visi, Rainer Hinz, Federico Turkheimer, Isabel Lewzey, Karl Herholz, Andreas H. Jacobs, Clive Holmes
Format: Article
Language:English
Published: Open Exploration Publishing Inc. 2023-03-01
Series:Exploration of Neuroscience
Subjects:
Online Access:https://www.explorationpub.com/Journals/en/Article/100612