Notch Signaling Activates Stem Cell Properties of Müller Glia through Transcriptional Regulation and Skp2-mediated Degradation of p27Kip1.

Notch Signaling Activates Stem Cell Properties of Müller Glia through Transcriptional Regulation and Skp2-mediated Degradation of p27Kip1.

Müller glia (MG), the sole glial cells generated by retinal progenitors, have emerged as a viable cellular target for therapeutic regeneration in degenerative blinding diseases, as they possess dormant stem cell properties. However, the mammalian MG does not display the neurogenic potential of their...

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Bibliographic Details
Main Authors: Carolina Beltrame Del Debbio, Qulsum Mir, Sowmya Parameswaran, Saumi Mathews, Xiaohuan Xia, Li Zheng, Andrew J Neville, Iqbal Ahmad
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4806989?pdf=render

Internet

http://europepmc.org/articles/PMC4806989?pdf=render

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