Synthesis and metabolism of leukotrienes in γ-glutamyl transpeptidase deficiency
Leukotrienes (LTs) are active lipid mediators derived in the 5-lipoxygenase pathway. LTC4, the primary cysteinyl LT, is cleaved by γ-glutamyl transpeptidase (GGT), resulting in LTD4. We studied the synthesis and metabolism of LTs in three patients with GGT deficiency. LTs were analyzed in urine, pla...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2004-05-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520318307 |