IRF7-deficient MDCK cell based on CRISPR/Cas9 technology for enhancing influenza virus replication and improving vaccine production

IRF7-deficient MDCK cell based on CRISPR/Cas9 technology for enhancing influenza virus replication and improving vaccine production

The influenza virus is a cause of seasonal epidemic disease and enormous economic injury. The best way to control influenza outbreaks is through vaccination. The Madin-Darby canine kidney cell line (MDCK) is currently approved to manufacture influenza vaccines. However, the viral load from cell-base...

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Bibliographic Details
Main Authors: Oraphan Mayuramart, Witthaya Poomipak, Somruthai Rattanaburi, Kritsada Khongnomnan, Songtham Anuntakarun, Suthat Saengchoowong, Tanit Chavalit, Naphat Chantaravisoot, Sunchai Payungporn
Format: Article
Language:English
Published: PeerJ Inc. 2022-09-01
Series:PeerJ
Subjects:
CRISPR-Cas9
IRF7
MDCK
Influenza
Interferon
Vaccine production
Online Access:https://peerj.com/articles/13989.pdf

Internet

https://peerj.com/articles/13989.pdf

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