Next-Generation Drugs and Probes for Chromatin Biology: From Targeted Protein Degradation to Phase Separation

Next-Generation Drugs and Probes for Chromatin Biology: From Targeted Protein Degradation to Phase Separation

Chromatin regulation is a critical aspect of nuclear function. Recent advances have provided detailed information about dynamic three-dimensional organization of chromatin and its regulatory factors. Mechanisms crucial for normal nuclear function and epigenetic control include compartmentalization o...

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Bibliographic Details
Main Authors: Katerina Cermakova, H. Courtney Hodges
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Molecules
Subjects:
degron
PROTAC
VHL
cereblon
rapamycin
FRB
FKBP
Halo-tag
SNAP-tag
chemically induced proximity
Online Access:http://www.mdpi.com/1420-3049/23/8/1958

Internet

http://www.mdpi.com/1420-3049/23/8/1958

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