Diverse functionalization of Aurora-A kinase at specified surface and buried sites by native chemical modification.

The ability to obtain a homogeneous sample of protein is invaluable when studying the effect of alterations such as post-translational modifications (PTMs). Selective functionalization of a protein to investigate the effect of PTMs on its structure or activity can be achieved by chemical modificatio...

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Bibliographic Details
Main Authors: Fiona Rowan, Meirion Richards, Marcella Widya, Richard Bayliss, Julian Blagg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4122486?pdf=render