Toxicity evaluation of 6-mercaptopurine-Chitosan nanoparticles in rats

Background: The 6-mercaptopurine (6-MP) is an effective immunosuppressant and anti-cancer drug. However, the usage of 6-MP is limited due to its well-known side effects, such as myelotoxicity and hepato-renal toxicity. To curtail the potential toxic effects, we have used chitosan as a natural biodeg...

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Bibliographic Details
Main Authors: Prem Kumar Govindappa, Darukeshwara Joladarashi, Raghavendra Lakshmana Shetty Hallur, Jagadeesh S. Sanganal, Ayyalasomayajula Ratna Phani
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Saudi Pharmaceutical Journal
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016419301598