FBXO38 mediates FGL1 ubiquitination and degradation to enhance cancer immunity and suppress inflammation

FBXO38 mediates FGL1 ubiquitination and degradation to enhance cancer immunity and suppress inflammation

Summary: Upregulation of FGL1 helps tumors escape from immune surveillance, and therapeutic antibodies targeting FGL1 have potential as another immune checkpoint inhibitor. However, the underlying mechanism of high FGL1 protein level in cancers is not well defined. Here, we report that FBXO38 intera...

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Bibliographic Details
Main Authors: Tongguan Tian, Xiao Xie, Wanwan Yi, Yuefan Zhou, Yixin Xu, Zhenxiang Wang, Junjing Zhang, Mingen Lin, Ruonan Zhang, Zhongwei Lv, Xinxing Li, Lei Lv, Yanping Xu
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Cell Reports
Subjects:
CP: Immunology
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723013748

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http://www.sciencedirect.com/science/article/pii/S2211124723013748

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