Activation of GPR119 Stimulates Human β-Cell Replication and Neogenesis in Humanized Mice with Functional Human Islets
Using humanized mice with functional human islets, we investigated whether activating GPR119 by PSN632408, a small molecular agonist, can stimulate human β-cell regeneration in vivo. Human islets were transplanted under the left kidney capsule of immunodeficient mice with streptozotocin- (STZ-) indu...
| Main Authors: | , , , , , , , , |
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| 格式: | 文件 |
| 语言: | English |
| 出版: |
Wiley
2016-01-01
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| 丛编: | Journal of Diabetes Research |
| 在线阅读: | http://dx.doi.org/10.1155/2016/1620821 |