A multi-organ-on-chip to recapitulate the infiltration and the cytotoxic activity of circulating NK cells in 3D matrix-based tumor model

A multi-organ-on-chip to recapitulate the infiltration and the cytotoxic activity of circulating NK cells in 3D matrix-based tumor model

The success of immunotherapeutic approaches strictly depends on the immune cells interaction with cancer cells. While conventional in vitro cell cultures under-represent the complexity and dynamic crosstalk of the tumor microenvironment, animal models do not allow deciphering the anti-tumor activity...

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Bibliographic Details
Main Authors: Monica Marzagalli, Giorgia Pelizzoni, Arianna Fedi, Chiara Vitale, Fabrizio Fontana, Silvia Bruno, Alessandro Poggi, Alessandra Dondero, Maurizio Aiello, Roberta Castriconi, Cristina Bottino, Silvia Scaglione
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
immune-organ-on-chip
3D human tumor model
natural killer cells
neuroblastoma
cells migration
cells infiltration
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.945149/full

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https://www.frontiersin.org/articles/10.3389/fbioe.2022.945149/full

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