Update on the Genetic Polymorphisms of Drug-Metabolizing Enzymes in Antiepileptic Drug Therapy

Update on the Genetic Polymorphisms of Drug-Metabolizing Enzymes in Antiepileptic Drug Therapy

Genetic polymorphisms in the genes that encode drug-metabolizing enzymes are implicated in the inter-individual variability in the pharmacokinetics and pharmaco-dynamics of antiepileptic drugs (AEDs). However, the clinical impact of these polymorphisms on AED therapy still remains controversial. The...

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Bibliographic Details
Main Authors: Junji Saruwatari, Takateru Ishitsu, Kazuko Nakagawa
Format: Article
Language:English
Published: MDPI AG 2010-08-01
Series:Pharmaceuticals
Subjects:
pharmacogenetics
genetic polymorphisms
antiepileptic drugs
drug-metabolizing enzyme
population pharmacokinetics
Online Access:http://www.mdpi.com/1424-8247/3/8/2709/

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http://www.mdpi.com/1424-8247/3/8/2709/

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