Stepwise Glucoheptoamidation of Poly(Amidoamine) Dendrimer G3 to Tune Physicochemical Properties of the Potential Drug Carrier: In Vitro Tests for Cytisine Conjugates

Stepwise Glucoheptoamidation of Poly(Amidoamine) Dendrimer G3 to Tune Physicochemical Properties of the Potential Drug Carrier: In Vitro Tests for Cytisine Conjugates

Third-generation poly(amidoamine) dendrimer (PAMAM) was modified by stepwise primary amine group amidation with <span style="font-variant: small-caps;">d</span>-glucoheptono-1,4-lactone. The physicochemical properties of the conjugates—size, ζ potential in lysosomal pH 5 and in...

Descripción completa

Detalles Bibliográficos
Autores principales: Anna Czerniecka-Kubicka, Piotr Tutka, Marek Pyda, Małgorzata Walczak, Łukasz Uram, Maria Misiorek, Ewelina Chmiel, Stanisław Wołowiec
Formato: Artículo
Lenguaje:English
Publicado: MDPI AG 2020-05-01
Colección:Pharmaceutics
Materias:
PAMAM G3 dendrimer
glucoheptoamidation
dynamic light scattering
differential scanning calorimetry
cytisine conjugate
cytotoxicity
Acceso en línea:https://www.mdpi.com/1999-4923/12/5/473

Internet

https://www.mdpi.com/1999-4923/12/5/473

Ejemplares similares