Increased serum extrachromosomal circular DNA SORBS1circle level is associated with insulin resistance in patients with newly diagnosed type 2 diabetes mellitus

Increased serum extrachromosomal circular DNA SORBS1circle level is associated with insulin resistance in patients with newly diagnosed type 2 diabetes mellitus

Abstract Background Extrachromosomal circular DNAs (eccDNAs) exist in human blood and somatic cells, and are essential for oncogene plasticity and drug resistance. However, the presence and impact of eccDNAs in type 2 diabetes mellitus (T2DM) remains inadequately understood. Methods We purified and...

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Bibliographic Details
Main Authors: Xiang Kong, Shu-jun Wan, Tian-bing Chen, Lan Jiang, Yu-jie Xing, Ya-ping Bai, Qiang Hua, Xin-ming Yao, Yong-li Zhao, Hong-mei Zhang, De-guo Wang, Qing Su, Kun Lv
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Cellular & Molecular Biology Letters
Subjects:
Extrachromosomal circular DNAs
T2DM
SORBS1
Insulin resistance
Online Access:https://doi.org/10.1186/s11658-023-00530-0

Internet

https://doi.org/10.1186/s11658-023-00530-0

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