Effects of ulotaront on brain circuits of reward, working memory, and emotion processing in healthy volunteers with high or low schizotypy

Effects of ulotaront on brain circuits of reward, working memory, and emotion processing in healthy volunteers with high or low schizotypy

Abstract Ulotaront, a trace amine-associated receptor 1 (TAAR1) and serotonin 5-HT1A receptor agonist without antagonist activity at dopamine D2 or the serotonin 5-HT2A receptors, has demonstrated efficacy in the treatment of schizophrenia. Here we report the phase 1 translational studies that profi...

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Bibliographic Details
Main Authors: Francesca Perini, Jadwiga Maria Nazimek, Shane Mckie, Liliana P. Capitão, Jessica Scaife, Deepa Pal, Michael Browning, Gerard R. Dawson, Hiroyuki Nishikawa, Una Campbell, Seth C. Hopkins, Antony Loebel, Rebecca Elliott, Catherine J. Harmer, Bill Deakin, Kenneth S. Koblan
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Schizophrenia
Online Access:https://doi.org/10.1038/s41537-023-00385-6

Internet

https://doi.org/10.1038/s41537-023-00385-6

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