Electrostatic Interaction with the Bacterial Cell Envelope Tunes the Lytic Activity of Two Novel Peptidoglycan Hydrolases

Electrostatic Interaction with the Bacterial Cell Envelope Tunes the Lytic Activity of Two Novel Peptidoglycan Hydrolases

ABSTRACT Peptidoglycan (PG) hydrolases, due to their crucial role in the metabolism of the bacterial cell wall (CW), are increasingly being considered suitable targets for therapies, and a potent alternative to conventional antibiotics. In the light of contradictory data reported, detailed mechanism...

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Bibliographic Details
Main Authors: Alicja Wysocka, Łukasz Łężniak, Elżbieta Jagielska, Izabela Sabała
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:Microbiology Spectrum
Subjects:
peptidoglycan
hydrolase
electrostatics
Staphylococcus aureus
cell wall
enzybiotics
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00455-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.00455-22

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