Combination Treatment With Inhibitors of ERK and Autophagy Enhances Antitumor Activity of Betulinic Acid in Non–small-Cell Lung Cancer In Vivo and In Vitro

Combination Treatment With Inhibitors of ERK and Autophagy Enhances Antitumor Activity of Betulinic Acid in Non–small-Cell Lung Cancer In Vivo and In Vitro

Aberrant activation of the Ras–ERK signaling pathway drives many important cancer phenotypes, and several inhibitors targeting such pathways are under investigation and/or approved by the FDA as single- or multi-agent therapy for patients with melanoma and non–small-cell lung cancer (NSCLC). Here, w...

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Bibliographic Details
Main Authors: Chao-Yue Sun, Di Cao, Qian-Nan Ren, Shan-Shan Zhang, Ning-Ning Zhou, Shi-Juan Mai, Bing Feng, Hui-Yun Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
lung cancer
betulinic acid
autophagy
apoptosis
ERK
combination
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.684243/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.684243/full

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