Disrupted Mitochondrial Network Drives Deficits of Learning and Memory in a Mouse Model of <i>FOXP1</i> Haploinsufficiency

Disrupted Mitochondrial Network Drives Deficits of Learning and Memory in a Mouse Model of <i>FOXP1</i> Haploinsufficiency

Reduced cognitive flexibility, characterized by restricted interests and repetitive behavior, is associated with atypical memory performance in autism spectrum disorder (ASD), suggesting hippocampal dysfunction. FOXP1 syndrome is a neurodevelopmental disorder characterized by ASD, language deficits,...

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Bibliographic Details
Main Authors: Jing Wang, Gudrun A. Rappold, Henning Fröhlich
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Genes
Subjects:
FOXP1 syndrome
<i>Foxp1</i><sup>+/−</sup> mouse
hippocampus
associative learning
autism spectrum disorder
mitochondrial dysfunction
Online Access:https://www.mdpi.com/2073-4425/13/1/127

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https://www.mdpi.com/2073-4425/13/1/127

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