CBX7 Induces Self-Renewal of Human Normal and Malignant Hematopoietic Stem and Progenitor Cells by Canonical and Non-canonical Interactions

CBX7 Induces Self-Renewal of Human Normal and Malignant Hematopoietic Stem and Progenitor Cells by Canonical and Non-canonical Interactions

Summary: In this study, we demonstrate that, among all five CBX Polycomb proteins, only CBX7 possesses the ability to control self-renewal of human hematopoietic stem and progenitor cells (HSPCs). Xenotransplantation of CBX7-overexpressing HSPCs resulted in increased multi-lineage long-term engraftm...

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Bibliographic Details
Main Authors: Johannes Jung, Sonja C. Buisman, Ellen Weersing, Albertina Dethmers-Ausema, Erik Zwart, Hein Schepers, Mike R. Dekker, Seka S. Lazare, Franziska Hammerl, Yulia Skokova, Susanne M. Kooistra, Karin Klauke, Raymond A. Poot, Leonid V. Bystrykh, Gerald de Haan
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719300683

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http://www.sciencedirect.com/science/article/pii/S2211124719300683

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