UBE2G1 governs the destruction of cereblon neomorphic substrates

UBE2G1 governs the destruction of cereblon neomorphic substrates

The cereblon modulating agents (CMs) including lenalidomide, pomalidomide and CC-220 repurpose the Cul4-RBX1-DDB1-CRBN (CRL4CRBN) E3 ubiquitin ligase complex to induce the degradation of specific neomorphic substrates via polyubiquitination in conjunction with E2 ubiquitin-conjugating enzymes, which...

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Bibliographic Details
Main Authors: Gang Lu, Stephanie Weng, Mary Matyskiela, Xinde Zheng, Wei Fang, Scott Wood, Christine Surka, Reina Mizukoshi, Chin-Chun Lu, Derek Mendy, In Sock Jang, Kai Wang, Mathieu Marella, Suzana Couto, Brian Cathers, James Carmichael, Philip Chamberlain, Mark Rolfe
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-09-01
Series:eLife
Subjects:
ubiquitination
cereblon
immunomodulatory drugs
cereblon modulating agents
PROTAC
Online Access:https://elifesciences.org/articles/40958

Internet

https://elifesciences.org/articles/40958

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