Natural killer cell activation by respiratory syncytial virus‐specific antibodies is decreased in infants with severe respiratory infections and correlates with Fc‐glycosylation

Natural killer cell activation by respiratory syncytial virus‐specific antibodies is decreased in infants with severe respiratory infections and correlates with Fc‐glycosylation

Abstract Objectives Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infections in infants, and there is no vaccine available. In early life, the most important contributors to protection against infectious diseases are the innate immune response and maternal anti...

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Bibliographic Details
Main Authors: Elisabeth A vanErp, Anke J Lakerveld, Erik deGraaf, Mads D Larsen, Rutger M Schepp, Agnes L Hipgrave Ederveen, Inge ML Ahout, Cornelis AM deHaan, Manfred Wuhrer, Willem Luytjes, Gerben Ferwerda, Gestur Vidarsson, Puck B vanKasteren
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Clinical & Translational Immunology
Subjects:
antibody‐dependent cell‐mediated cytotoxicity
Fc‐mediated effector functions
fucosylation
interferon‐gamma
NK cell
respiratory syncytial virus
Online Access:https://doi.org/10.1002/cti2.1112

Internet

https://doi.org/10.1002/cti2.1112

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