The Novel <i>h</i>DHODH Inhibitor MEDS433 Prevents Influenza Virus Replication by Blocking Pyrimidine Biosynthesis

The Novel <i>h</i>DHODH Inhibitor MEDS433 Prevents Influenza Virus Replication by Blocking Pyrimidine Biosynthesis

The pharmacological management of influenza virus (IV) infections still poses a series of challenges due to the limited anti-IV drug arsenal. Therefore, the development of new anti-influenza agents effective against antigenically different IVs is therefore an urgent priority. To meet this need, host...

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Bibliographic Details
Main Authors: Giulia Sibille, Anna Luganini, Stefano Sainas, Donatella Boschi, Marco Lucio Lolli, Giorgio Gribaudo
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Viruses
Subjects:
influenza virus
host-targeting antivirals
de novo pyrimidine biosynthesis
dihydroorotate dehydrogenase
MEDS433
dipyridamole
Online Access:https://www.mdpi.com/1999-4915/14/10/2281

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https://www.mdpi.com/1999-4915/14/10/2281

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