Formation of Ciprofloxacin–Isonicotinic Acid Cocrystal Using Mechanochemical Synthesis Routes—An Investigation into Critical Process Parameters

Formation of Ciprofloxacin–Isonicotinic Acid Cocrystal Using Mechanochemical Synthesis Routes—An Investigation into Critical Process Parameters

The mechanochemical synthesis of cocrystals has been introduced as a promising approach of formulating poorly water-soluble active pharmaceutical ingredients (APIs). In this study, hot-melt extrusion (HME) as a continuous process and grinding and ball milling as batch processes were employed to expl...

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Bibliographic Details
Main Authors: Maryam Karimi-Jafari, Ahmad Ziaee, Emmet O’Reilly, Denise Croker, Gavin Walker
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Pharmaceutics
Subjects:
cocrystal
mechanochemical synthesis
hot-melt extrusion
ball milling
grinding
solid state chemistry
Online Access:https://www.mdpi.com/1999-4923/14/3/634

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https://www.mdpi.com/1999-4923/14/3/634

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