Driver mutation zygosity is a critical factor in predicting clonal hematopoiesis transformation risk

Driver mutation zygosity is a critical factor in predicting clonal hematopoiesis transformation risk

Abstract Clonal hematopoiesis (CH) can be caused by either single gene mutations (eg point mutations in JAK2 causing CHIP) or mosaic chromosomal alterations (e.g., loss of heterozygosity at chromosome 9p). CH is associated with a significantly increased risk of hematologic malignancies. However, the...

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Bibliographic Details
Main Authors: Ashwin Kishtagari, M. A. Wasay Khan, Yajing Li, Caitlyn Vlasschaert, Naimisha Marneni, Alexander J. Silver, Kelly von Beck, Travis Spaulding, Shannon Stockton, Christina Snider, Andrew Sochacki, Dixon Dorand, Taralynn M. Mack, P. Brent Ferrell, Yaomin Xu, Cosmin A. Bejan, Michael R. Savona, Alexander G. Bick
Format: Article
Language:English
Published: Nature Publishing Group 2024-01-01
Series:Blood Cancer Journal
Online Access:https://doi.org/10.1038/s41408-023-00974-9

Internet

https://doi.org/10.1038/s41408-023-00974-9

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