Phosphorylated TDP-43 aggregates in skeletal and cardiac muscle are a marker of myogenic degeneration in amyotrophic lateral sclerosis and various conditions

Phosphorylated TDP-43 aggregates in skeletal and cardiac muscle are a marker of myogenic degeneration in amyotrophic lateral sclerosis and various conditions

Abstract Background Amyotrophic lateral sclerosis (ALS) is characterized pathologically by the occurrence of phosphorylated TDP-43 (pTDP-43)-immunoreactive neuronal and glial inclusions in the central nervous system. Recent studies have shown that pTDP-43 aggregates also occur in the skeletal muscle...

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書目詳細資料
Main Authors: Fumiaki Mori, Mari Tada, Tomoya Kon, Yasuo Miki, Kunikazu Tanji, Hidekachi Kurotaki, Masahiko Tomiyama, Tomohiko Ishihara, Osamu Onodera, Akiyoshi Kakita, Koichi Wakabayashi
格式: Article
語言:English
出版: BMC 2019-10-01
叢編:Acta Neuropathologica Communications
主題:
Amyotrophic lateral sclerosis
Myocardium
Myogenic degeneration
Skeletal muscle
TDP-43
在線閱讀:http://link.springer.com/article/10.1186/s40478-019-0824-1

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http://link.springer.com/article/10.1186/s40478-019-0824-1

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