Prevention of C5aR1 signaling delays microglial inflammatory polarization, favors clearance pathways and suppresses cognitive loss

Prevention of C5aR1 signaling delays microglial inflammatory polarization, favors clearance pathways and suppresses cognitive loss

Abstract Background Pharmacologic inhibition of C5aR1, a receptor for the complement activation proinflammatory fragment, C5a, suppressed pathology and cognitive deficits in Alzheimer's disease (AD) mouse models. To validate that the effect of the antagonist was specifically via C5aR1 inhibitio...

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Bibliographic Details
Main Authors: Michael X. Hernandez, Shan Jiang, Tracy A. Cole, Shu-Hui Chu, Maria I. Fonseca, Melody J. Fang, Lindsay A. Hohsfield, Maria D. Torres, Kim N. Green, Rick A. Wetsel, Ali Mortazavi, Andrea J. Tenner
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Molecular Neurodegeneration
Subjects:
C5a
C5a receptor
Alzheimer’s disease
Complement
Microglia
Mouse models
Online Access:http://link.springer.com/article/10.1186/s13024-017-0210-z

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http://link.springer.com/article/10.1186/s13024-017-0210-z

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