Brief research report: Repurposing pentoxifylline to treat intense acute swimming–Induced delayed-onset muscle soreness in mice: Targeting peripheral and spinal cord nociceptive mechanisms

Brief research report: Repurposing pentoxifylline to treat intense acute swimming–Induced delayed-onset muscle soreness in mice: Targeting peripheral and spinal cord nociceptive mechanisms

In this study, we pursue determining the effect of pentoxifylline (Ptx) in delayed-onset muscle soreness (DOMS) triggered by exposing untrained mice to intense acute swimming exercise (120 min), which, to our knowledge, has not been investigated. Ptx treatment (1.5, 4.5, and 13.5 mg/kg; i.p., 30 min...

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Bibliographic Details
Main Authors: Sergio M. Borghi, Tiago H. Zaninelli, Telma Saraiva-Santos, Mariana M. Bertozzi, Renato D. R. Cardoso, Thacyana T. Carvalho, Camila R. Ferraz, Doumit Camilios-Neto, Fernando Q. Cunha, Thiago M. Cunha, Felipe A. Pinho-Ribeiro, Rubia Casagrande, Waldiceu A. Verri
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Pharmacology
Subjects:
pentoxifylline
muscle mechanical hyperalgesia
cytokine
oxidative stress
glial cells
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.950314/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.950314/full

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