Chimeric antigen receptors enable superior control of HIV replication by rapidly killing infected cells.

Chimeric antigen receptors enable superior control of HIV replication by rapidly killing infected cells.

Engineered T cells hold great promise to become part of an effective HIV cure strategy, but it is currently unclear how best to redirect T cells to target HIV. To gain insight, we generated engineered T cells using lentiviral vectors encoding one of three distinct HIV-specific T cell receptors (TCRs...

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Bibliographic Details
Main Authors: Yuqi Zhou, Julie Jadlowsky, Caitlin Baiduc, Alex W Klattenhoff, Zhilin Chen, Alan D Bennett, Nicholas J Pumphrey, Bent K Jakobsen, James L Riley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-12-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1011853

Internet

https://doi.org/10.1371/journal.ppat.1011853

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