In silico characterization of aryl benzoyl hydrazide derivatives as potential inhibitors of RdRp enzyme of H5N1 influenza virus

In silico characterization of aryl benzoyl hydrazide derivatives as potential inhibitors of RdRp enzyme of H5N1 influenza virus

RNA-dependent RNA polymerase (RdRp) is a potential therapeutic target for the discovery of novel antiviral agents for the treatment of life-threatening infections caused by newly emerged strains of the influenza virus. Being one of the most conserved enzymes among RNA viruses, RdRp and its inhibitor...

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Bibliographic Details
Main Authors: Abhishek Ghosh, Parthasarathi Panda, Amit Kumar Halder, Maria Natalia D. S. Cordeiro
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
influenza virus
RNA-dependent RNA polymerase
QSAR
pharmacophore mapping
molecular dynamics
in silico
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1004255/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1004255/full

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