Lentiviral vector mediated thymidine kinase expression in pluripotent stem cells enables removal of tumorigenic cells.

Lentiviral vector mediated thymidine kinase expression in pluripotent stem cells enables removal of tumorigenic cells.

Embryonic stem cells (ES) and induced pluripotent stem (iPS) cells represent promising tools for cell-based therapies and regenerative medicine. Nevertheless, implantation of ES cell derived differentiated cells holds the risk of teratoma formation due to residual undifferentiated cells. In order to...

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Bibliographic Details
Main Authors: Tiong-Ti Lim, Caroline Geisen, Michael Hesse, Bernd K Fleischmann, Katrin Zimmermann, Alexander Pfeifer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3728319?pdf=render

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http://europepmc.org/articles/PMC3728319?pdf=render

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