The synergic effects of presynaptic calcium channel antagonists purified from spiders on memory elimination of glutamate-induced excitotoxicity in the rat hippocampus trisynaptic circuit

The synergic effects of presynaptic calcium channel antagonists purified from spiders on memory elimination of glutamate-induced excitotoxicity in the rat hippocampus trisynaptic circuit

The hippocampus is a complex area of the mammalian brain and is responsible for learning and memory. The trisynaptic circuit engages with explicit memory. Hippocampal neurons express two types of presynaptic voltage-gated calcium channels (VGCCs) comprising N and P/Q-types. These VGCCs play a vital...

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Bibliographic Details
Main Authors: Mohammad Keimasi, Kowsar Salehifard, Noushin Mirshah Jafar Esfahani, Fariba Esmaeili, Arman Farghadani, Mohammadreza Amirsadri, Mohammadjavad Keimasi, Maryam Noorbakhshnia, Majid Moradmand, Mohammad Reza Mofid
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Molecular Biosciences
Subjects:
cognitive dysfunction
memory
calcium channel blockers
calcium channel Cav2.2 (N type)
calcium channel Cav2.1 (P/Q type)
long-term potentiation
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1243976/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2023.1243976/full

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