The key role of gut–liver axis in pyrrolizidine alkaloid-induced hepatotoxicity and enterotoxicity

The key role of gut–liver axis in pyrrolizidine alkaloid-induced hepatotoxicity and enterotoxicity

Pyrrolizidine alkaloids (PAs) are the most common phytotoxins with documented human hepatotoxicity. PAs require metabolic activation by cytochromes P450 to generate toxic intermediates which bind to proteins and form protein adducts, thereby causing cytotoxicity. This study investigated the role of...

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Bibliographic Details
Main Authors: Yisheng He, Jiang Ma, Xiaoyu Fan, Liang Ding, Xinxin Ding, Qing-Yu Zhang, Ge Lin
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Pyrrolizidine alkaloid
Cytochrome P450
Inflammatory bowel disease
Intestinal injury
Liver injury
Gut–liver axis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521002628

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