Cortical cerebrovascular and metabolic perturbations in the 5xFAD mouse model of Alzheimer’s disease

Cortical cerebrovascular and metabolic perturbations in the 5xFAD mouse model of Alzheimer’s disease

IntroductionThe 5xFAD mouse is a popular model of familial Alzheimer’s disease (AD) that is characterized by early beta-amyloid (Aβ) deposition and cognitive decrements. Despite numerous studies, the 5xFAD mouse has not been comprehensively phenotyped for vascular and metabolic perturbations over it...

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Bibliographic Details
Main Authors: Amandine Jullienne, Jenny I. Szu, Ryan Quan, Michelle V. Trinh, Tannoz Norouzi, Brenda P. Noarbe, Amanda A. Bedwell, Kierra Eldridge, Scott C. Persohn, Paul R. Territo, Andre Obenaus
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
cerebrovasculature
PET
MRI
sex
blood–brain barrier
vessels
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1220036/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2023.1220036/full

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