Detection of Genetic Overlap Between Rheumatoid Arthritis and Systemic Lupus Erythematosus Using GWAS Summary Statistics

Detection of Genetic Overlap Between Rheumatoid Arthritis and Systemic Lupus Erythematosus Using GWAS Summary Statistics

BackgroundClinical and epidemiological studies have suggested systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are comorbidities and common genetic etiologies can partly explain such coexistence. However, shared genetic determinations underlying the two diseases remain largely unknow...

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Bibliographic Details
Main Authors: Haojie Lu, Jinhui Zhang, Zhou Jiang, Meng Zhang, Ting Wang, Huashuo Zhao, Ping Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Genetics
Subjects:
rheumatoid arthritis
systemic lupus erythematosus
harmonic mean P-value
conjunction conditional false discover rate
pleiotropic genes
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.656545/full

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https://www.frontiersin.org/articles/10.3389/fgene.2021.656545/full

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