Systemic Administration and Targeted Delivery of Immunogenic Oncolytic Adenovirus Encapsulated in Extracellular Vesicles for Cancer Therapies

Systemic Administration and Targeted Delivery of Immunogenic Oncolytic Adenovirus Encapsulated in Extracellular Vesicles for Cancer Therapies

Oncolytic viruses (OV) are engineered to infect, replicate in and kill cancer cells. Currently, the OV therapeutic approach is mainly restricted to neoplasia amenable to direct local administration of viral particles, while the possibility of a systemic delivery of cancer-tropic viruses would extend...

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Bibliographic Details
Main Authors: Mariangela Garofalo, Alessandro Villa, Nicoletta Rizzi, Lukasz Kuryk, Vincenzo Mazzaferro, Paolo Ciana
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Viruses
Subjects:
Oncolytic adenovirus
extracellular vesicles
lung cancer
immunocompetent mouse model
in vivo imaging
Online Access:http://www.mdpi.com/1999-4915/10/10/558

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http://www.mdpi.com/1999-4915/10/10/558

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