Activated Hepatic Stellate Cells Induce Infiltration and Formation of CD163+ Macrophages via CCL2/CCR2 Pathway

Activated Hepatic Stellate Cells Induce Infiltration and Formation of CD163+ Macrophages via CCL2/CCR2 Pathway

Background: Activated hepatic stellate cells (aHSCs) regulate the function of immune cells during liver fibrosis. As major innate cells in the liver, macrophages have inducible plasticity. Nevertheless, the mechanisms through which aHSCs regulate macrophages' phenotype and function during liver...

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Bibliographic Details
Main Authors: Sujuan Xi, Xiaoyan Zheng, Xiangyong Li, Yuming Jiang, Yuankai Wu, Jiao Gong, Yusheng Jie, Zhanyi Li, Jing Cao, Liuping Sha, Min Zhang, Yutian Chong
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Medicine
Subjects:
activated hepatic stellate cells
liver fibrosis
M2 macrophage
CCL2
hepatitis B
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.627927/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2021.627927/full

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