Hepatic non-parenchymal S100A9-TLR4-mTORC1 axis normalizes diabetic ketogenesis

Hepatic non-parenchymal S100A9-TLR4-mTORC1 axis normalizes diabetic ketogenesis

Excess ketogenesis can lead to ketoacidosis, a serious complication in patients with diabetes. Here the authors report an insulin independent pathway, the hepatic nonparenchymal S100A9-TLR4-mTORC1 axis, that is able to normalize diabetic ketogenesis and pre-clinical data to suggest potential for dev...

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Bibliographic Details
Main Authors: Gloria Ursino, Giorgio Ramadori, Anna Höfler, Soline Odouard, Pryscila D. S. Teixeira, Florian Visentin, Christelle Veyrat-Durebex, Giulia Lucibello, Raquel Firnkes, Serena Ricci, Claudia R. Vianna, Lin Jia, Mirjam Dirlewanger, Philippe Klee, Joel K. Elmquist, Johannes Roth, Thomas Vogl, Valérie M. Schwitzgebel, François R. Jornayvaz, Andreas Boland, Roberto Coppari
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-31803-5

Internet

https://doi.org/10.1038/s41467-022-31803-5

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