Enhancing chemical and physical stability of pharmaceuticals using freeze-thaw method: challenges and opportunities for process optimization through quality by design approach

Enhancing chemical and physical stability of pharmaceuticals using freeze-thaw method: challenges and opportunities for process optimization through quality by design approach

Abstract The freeze-thaw (F/T) method is commonly employed during the processing and handling of drug substances to enhance their chemical and physical stability and obtain pharmaceutical applications such as hydrogels, emulsions, and nanosystems (e.g., supramolecular complexes of cyclodextrins and...

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Bibliographic Details
Main Authors: Sergio A. Bernal-Chávez, Alejandra Romero-Montero, Héctor Hernández-Parra, Sheila I. Peña-Corona, María L. Del Prado-Audelo, Sergio Alcalá-Alcalá, Hernán Cortés, Lashyn Kiyekbayeva, Javad Sharifi-Rad, Gerardo Leyva-Gómez
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Journal of Biological Engineering
Subjects:
Drug substances
Chemical stability
Physical stability
Hydrogels
Chemical properties
Pharmaceutical applications
Online Access:https://doi.org/10.1186/s13036-023-00353-9

Internet

https://doi.org/10.1186/s13036-023-00353-9

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