NVP-CGM097, an HDM2 Inhibitor, Antagonizes ATP-Binding Cassette Subfamily B Member 1-Mediated Drug Resistance

NVP-CGM097, an HDM2 Inhibitor, Antagonizes ATP-Binding Cassette Subfamily B Member 1-Mediated Drug Resistance

Multidrug resistance (MDR) is a major challenge in the treatment of tumors. It refers to cancer cells become resistant to not only the therapeutic drug, but also cross-resistant to multiple drugs with distinct structures and mechanisms of action when they are exposed to a drug for a period of time....

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Bibliographic Details
Main Authors: Meng Zhang, Xuan-Yu Chen, Xing-Duo Dong, Jing-Quan Wang, Weiguo Feng, Qiu-Xu Teng, Qingbin Cui, Jing Li, Xiang-Qi Li, Zhe-Sheng Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Oncology
Subjects:
ABCB1
multidrug resistance
ABC transporter
NVP-CGM097
chemotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01219/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.01219/full

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