The Electrophysiological Determinants of Corticospinal Motor Neuron Vulnerability in ALS

The Electrophysiological Determinants of Corticospinal Motor Neuron Vulnerability in ALS

The brain is complex and heterogeneous. Even though numerous independent studies indicate cortical hyperexcitability as a potential contributor to amyotrophic lateral sclerosis (ALS) pathology, the mechanisms that are responsible for upper motor neuron (UMN) vulnerability remain elusive. To reveal t...

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Bibliographic Details
Main Authors: Javier H. Jara, Patrick L. Sheets, Maximiliano José Nigro, Mina Perić, Carolyn Brooks, Daniel B. Heller, Marco Martina, Pavle R. Andjus, P. Hande Ozdinler
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
amyotrophic lateral sclerosis
corticospinal motor neurons
microcircuit
upper motor neurons
hereditary spastic paraplegia
primary lateral sclerosis
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00073/full

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https://www.frontiersin.org/article/10.3389/fnmol.2020.00073/full

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