The role of inflammasomes in human diseases and their potential as therapeutic targets

Abstract Inflammasomes are large protein complexes that play a major role in sensing inflammatory signals and triggering the innate immune response. Each inflammasome complex has three major components: an upstream sensor molecule that is connected to a downstream effector protein such as caspase-1...

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Bibliographic Details
Main Authors: Jing Yao, Keenan Sterling, Zhe Wang, Yun Zhang, Weihong Song
Format: Article
Language:English
Published: Nature Publishing Group 2024-01-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-023-01687-y